[病毒心肌炎与扩张型心肌病心肌中CAR的表达]
[Expression of CAR in myocardial of viral myocarditis and dilated cardiomyopathy].
作者信息
Xu Hong-Fei, Chen Jian-Lei, Da Xu-Ping, Wu Ke-Rong, Liu Guo-Qing, Zhao Zi-Qin, Han Xin-Hua
机构信息
Department of Forensic Medicine, Medical College of Nantong University, Nantong 226001, China.
出版信息
Fa Yi Xue Za Zhi. 2010 Oct;26(5):328-31.
OBJECTIVE
In order to improve accuracy and reliability of forensic diagnosis of sudden cardiac death, pathogenesis and relationship between the viral myocarditis (VMC) and dilated cardiomyopathy (DCM) were investigated.
METHODS
Improved immunohistochemical technique was used to detect the expression of the CAR in myocardium samples, including 22 deceased with VMC, 20 deceased with DCM and 16 control deceased.
RESULTS
The brown staining on the cell membrane of myocardium showed positive result. There was a prominent CAR expression in VMC group and DCM group, which were statistically significant difference compared with control group (P < 0.05).
CONCLUSION
The CAR expression showed significantly higher in VMC and DCM groups. The viral infection can result in myocardial necrosis and impaired cardiac functions. These abnormalities can trigger a cascade of events that contributed to the progress of VMC to DCM.
目的
为提高心脏性猝死法医诊断的准确性和可靠性，研究病毒性心肌炎（VMC）与扩张型心肌病（DCM）的发病机制及两者之间的关系。
方法
采用改良免疫组化技术检测心肌样本中柯萨奇病毒受体（CAR）的表达，其中包括22例VMC死亡者、20例DCM死亡者及16例对照死亡者。
结果
心肌细胞膜棕色染色呈阳性结果。VMC组和DCM组CAR表达显著，与对照组相比差异有统计学意义（P<0.05）。
结论
VMC组和DCM组CAR表达显著升高。病毒感染可导致心肌坏死及心功能受损。这些异常可引发一系列事件，促使VMC进展为DCM。
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