Xu Hong-fei, Li Yong-hong, Chen Yang, Cheng Li-bao
Department of Forensic Medicine, Wanna Medical College,Wuhu 241001,China.
Fa Yi Xue Za Zhi. 2006 Feb;22(1):12-4.
In order to improve the accuracy and reliability in sudden cardiac death, the pathogenesis and relationship between the viral myocarditis and dilated cardiomyopathy were investigated.
Improved immunohistochemical technique was adopted to detect the expression of the dystrophin in myocardium from 25 viral myocarditis, 28 dilated cardiomyopathy and 17 control cases including normal, coronary atherosclerotic heart disease and hypertension heart disease as control.
The positive rate of dystrophin protein expression in control group was 100%, that in viral myocarditis was 88%, and that in dilated cardiomyopathy was 57%, There were significant differences among three groups (P<0.05), and the correlation between viral myocarditis and dilated cardiomyopathy group (r = -0.526)were also found.
The myocardial cytoskeletal protein is disrupted in viral myocarditis and dilated cardiomyopathy, and the dystrophin protein may be involved in the pathogenesis of viral myocarditis and dilated cardiomyopathy. The viral infect and impair heart functions by cleaving host dystrophin proteins may ultimately contributes to the viral myocarditis to the converting from dilated cardiomyopathy.
为提高心脏性猝死诊断的准确性和可靠性，探讨病毒性心肌炎与扩张型心肌病的发病机制及两者之间的关系。
采用改良免疫组织化学技术检测25例病毒性心肌炎、28例扩张型心肌病患者及17例正常对照、冠状动脉粥样硬化性心脏病和高血压性心脏病患者心肌中抗肌萎缩蛋白的表达。
抗肌萎缩蛋白的阳性表达率在正常对照组为100%，病毒性心肌炎组为88%，扩张型心肌病组为57%，三组间差异有统计学意义（P<0.05），且病毒性心肌炎组与扩张型心肌病组之间存在相关性（r = -0.526）。
病毒性心肌炎和扩张型心肌病均存在心肌细胞骨架蛋白破坏，抗肌萎缩蛋白可能参与病毒性心肌炎和扩张型心肌病的发病机制，病毒感染通过裂解宿主抗肌萎缩蛋白损害心脏功能，可能是病毒性心肌炎向扩张型心肌病转变的原因。
