Demaret I, Lemaître A, Ansseau M
Service de Psychiatrie et Institut des Sciences Humaines et Sociales, Université de Liège, Belgique.
Rev Med Liege. 2010 Dec;65(12):681-7.
Before implementing the TADAM project in Belgium (a heroin-assisted treatment trial), our research team studied the trials in other countries. Since 1994, six randomised controlled trials have been developed using the same treatment model of heroin-assisted treatment (HAT). Each trial concluded that HAT had more efficacy than methadone treatment. We analysed those trials in order to find on which levels patients in a HAT treatment are expected to improve. Improvements appeared after at least six months on the level of street heroin use, (physical and mental) health and criminal behaviour. In the longer term, the continuation of treatment had positive but limited effects on the social level. Due to his higher cost, this treatment should remain a second-line treatment for this special target group: severe heroin addicts, using continuously street heroin in spite of a methadone treatment.
在比利时实施TADAM项目（一项海洛因辅助治疗试验）之前，我们的研究团队研究了其他国家的试验。自1994年以来，已经开展了六项随机对照试验，采用相同的海洛因辅助治疗（HAT）模式。每项试验都得出结论，海洛因辅助治疗比美沙酮治疗更有效。我们分析了这些试验，以找出接受海洛因辅助治疗的患者有望在哪些层面得到改善。在街头海洛因使用、（身体和精神）健康及犯罪行为层面，至少六个月后出现了改善。从长期来看，持续治疗对社会层面有积极但有限的影响。由于成本较高，这种治疗应仍然是针对这一特殊目标群体（重度海洛因成瘾者，尽管接受了美沙酮治疗仍持续使用街头海洛因）的二线治疗方法。
