通过钯催化的 N-芳基化反应，从 1,2-二氨基乙烷合成含有轴向手性 1,1'-联萘的偕二胺的模块化方法。
Modular approach for synthesis of vicinal diamines containing axial chiral 1,1'-binaphthyl from 1,2-diaminoethane by Pd-catalyzed N-arylation reactions.
机构信息
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, P R China.
出版信息
Org Lett. 2011 Mar 4;13(5):1146-9. doi: 10.1021/ol103169z. Epub 2011 Feb 2.
PMID:21288045
Abstract
A very convenient and efficient modular approach for the synthesis of vicinal diamines containing axial chiral 1,1'-binaphthyl from 1,2-diaminoethane by Pd-catalyzed N-arylation reactions has been developed. The resulting chiral diamines could be easily converted into NHC precursors, imidazole salts, in good yields.
摘要
已开发出一种非常方便、高效的模块方法，通过钯催化的 N-芳基化反应，从 1,2-二氨基乙烷合成含有轴向手性 1,1'-联萘的偕二胺。所得手性二胺可轻松转化为 NHC 前体、咪唑盐，产率良好。
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