Koike A, Wasserman K, Beaver W L, Weiler-Ravell D, McKenzie D K, Zanconato S
Department of Medicine, University of California, Harbor-UCLA Medical Center, Torrance 90509.
Adv Exp Med Biol. 1990;277:835-46. doi: 10.1007/978-1-4684-8181-5_95.
In this paper, we provided evidence to support the concept that work above the anaerobic threshold, measured by the V-slope method, is, in fact, performed partially anaerobically. In contrast, work performed below the anaerobic threshold is totally aerobic (Figure 2, 4 and 5). The VO2 at the transition from aerobic to partial anaerobic metabolism must depend on cardiovascular performance since it regulates the capillary PO2 level needed for O2 diffusion transport into the mitochondria (Figure 1). At high work rates, the capillary PO2 needed for the oxygen requirement might not be met by the cardiovascular oxygen supply. This would result in the oxygen consumed being less than the oxygen required by the working tissue (Figure 2), with the oxygen equivalent difference necessarily coming from anaerobic metabolism. The consequences are increased lactate formation and metabolic acidosis, and the physiological and biochemical disturbances which result from the latter.
在本文中，我们提供了证据来支持这一概念：通过V斜率法测量的无氧阈值以上的工作实际上部分是无氧进行的。相比之下，无氧阈值以下进行的工作完全是有氧的（图2、4和5）。从有氧代谢转变为部分无氧代谢时的VO2必须依赖于心血管功能，因为它调节氧气扩散进入线粒体所需的毛细血管PO2水平（图1）。在高工作强度下，心血管系统的氧气供应可能无法满足氧气需求所需的毛细血管PO2。这将导致消耗的氧气少于工作组织所需的氧气（图2），氧气当量差必然来自无氧代谢。其后果是乳酸生成增加和代谢性酸中毒，以及由后者导致的生理和生化紊乱。
