TRP 通道在肝细胞中的表达和功能。

Expression and function of TRP channels in liver cells.

机构信息

Department of Physiology, University of Adelaide, Adelaide, SA 5001, Australia.

出版信息

Adv Exp Med Biol. 2011;704:667-86. doi: 10.1007/978-94-007-0265-3_35.

Abstract

The liver plays a central role in whole body homeostasis by mediating the metabolism of carbohydrates, fats, proteins, drugs and xenobiotic compounds, and bile acid and protein secretion. Hepatocytes together with endothelial cells, Kupffer cells, smooth muscle cells, stellate and oval cells comprise the functioning liver. Many members of the TRP family of proteins are expressed in hepatocytes. However, knowledge of their cellular functions is limited. There is some evidence which suggests the involvement of TRPC1 in volume control, TRPV1 and V4 in cell migration, TRPC6 and TRPM7 in cell proliferation, and TRPPM in lysosomal Ca(2+) release. Altered expression of some TRP proteins, including TRPC6, TRPM2 and TRPV1, in tumorigenic cell lines may play roles in the development and progression of hepatocellular carcinoma and metastatic liver cancers. It is likely that future experiments will define important roles for other TRP proteins in the cellular functions of hepatocytes and other cell types of which the liver is composed.

摘要

肝脏通过调节碳水化合物、脂肪、蛋白质、药物和外源性化合物以及胆汁酸和蛋白质的分泌，在维持全身内环境稳定方面发挥着核心作用。肝细胞与内皮细胞、库普弗细胞、平滑肌细胞、星状细胞和卵圆细胞共同构成了有功能的肝脏。许多 TRP 蛋白家族成员在肝细胞中表达。然而，它们的细胞功能知之甚少。有一些证据表明 TRPC1 参与了体积调节，TRPV1 和 V4 参与了细胞迁移，TRPC6 和 TRPM7 参与了细胞增殖，而 TRPPM 则参与了溶酶体 Ca(2+)的释放。在肿瘤细胞系中，一些 TRP 蛋白（包括 TRPC6、TRPM2 和 TRPV1）的表达改变可能在肝细胞癌和转移性肝癌的发展和进展中发挥作用。未来的实验很可能会确定其他 TRP 蛋白在肝细胞和肝脏组成的其他细胞类型的细胞功能中的重要作用。