胼胝体切开术治疗药物难治性全身性癫痫发作。

Callosotomy for the treatment of drug resistant generalized seizures.

作者信息

Papo I, Quattrini A, Provinciali L, Rychlicki F, Del Pesce M, Paggi A, Ortenzi F, Recchioni M A, Censori B

机构信息

Neurosurgical Division, University Medical School, Ancona, Italy.

出版信息

Acta Neurochir Suppl (Wien). 1990;50:134-5. doi: 10.1007/978-3-7091-9104-0_27.

DOI:10.1007/978-3-7091-9104-0_27

PMID:2129084

Abstract

Fifteen patients have been followed for more than one year following callosotomy having presented with long standing epilepsy, no well defined focus amenable to radical excision, and severely incapacitating atonic seizures that were refractory to anticonvulsant therapy. Atonic fits have been reduced by more than 80% in thirteen patients, with two patients suffering long term sequelae (slight dysarthria in one, and dyslexia with mild visuo-spatial disturbances in another). Anticonvulsant therapy was still required post-operatively.

摘要

15例患者因长期癫痫、无明确可根治性切除的病灶以及抗惊厥治疗无效的严重致残性失张力发作接受胼胝体切开术，术后随访超过1年。13例患者的失张力发作减少了80%以上，2例患者出现长期后遗症（1例有轻度构音障碍，另1例有阅读障碍伴轻度视觉空间障碍）。术后仍需抗惊厥治疗。