Lukowsky A, Jahn S, von Baehr R
Institut für Medizinische Immunologie, Humboldt-Universität zu Berlin.
Allerg Immunol (Leipz). 1990;36(4):225-32.
The present study provides a survey on the structure and functions of human Vh-genes. The more than 100 individual gene segments on chromosome 14 are classified, according to sequence homologies, into 6 families. They differ very much in size and contain pseudogenes, form an interspersed cluster, exhibit homologies with mouse genes and have phylogenetically developed from a single primordial gene. There seem to be no association of antibody specificities with distinct Vh genes or families. Reports of preferential VH gene usage in the fetal stage or in autoantibody synthesis require confirmation. Vh genes for Ig production in the adult mammalian organism are, most probably randomly selected.
本研究对人类Vh基因的结构和功能进行了综述。14号染色体上的100多个单个基因片段根据序列同源性被分为6个家族。它们在大小上差异很大，包含假基因，形成一个散在的簇，与小鼠基因具有同源性，并且在系统发育上由单个原始基因进化而来。抗体特异性与不同的Vh基因或家族之间似乎没有关联。关于胎儿期或自身抗体合成中优先使用VH基因的报道需要证实。成年哺乳动物机体中用于产生Ig的Vh基因很可能是随机选择的。
