Wayne State University, Internal Medicine/Endocrinology, 4201 St. Antoine, Detroit, MI 48201, USA.
Expert Opin Pharmacother. 2011 Mar;12(4):641-6. doi: 10.1517/14656566.2011.556113. Epub 2011 Feb 4.
The historical background of the discovery of incretins became of particular interest when insulin response was found to be much more pronounced when glucose was given orally, rather than intravenously. The robust insulin secretion seen in response to oral glucose, as opposed to intravenous glucose, is due to incretin hormones. Since the discovery of incretins, the significance of sitagliptin and metformin combination therapy has become an essential strategy in combating diabetes. The use of combination therapy such as sitagliptin and metformin in achieving the desired level of glycemia in patients with diabetes is very important and is an additional armamentarium in the fight against diabetes.
This article reviews the history of incretins, the pathophysiology of diabetes and the use of sitagliptin and metformin combination therapy.
Achieving optimum blood glucose control is crucial in avoiding or at least delaying the progression of complications related to diabetes. Recently, it has become very clear that treatment with a single antidiabetic agent is often not successful in achieving glycemic control. Thus, many patients with type 2 diabetes require multiple combinations. Using sitagliptin and metformin combination therapy is an ideal strategy in the treatment of diabetes.
当人们发现葡萄糖经口服给予时，胰岛素的反应要比静脉内给予时明显得多，这一发现使肠促胰岛素的历史背景变得尤为重要。与静脉内给予葡萄糖相比，口服葡萄糖会引起更强的胰岛素分泌，这是由于肠促胰岛素激素的作用。自从发现肠促胰岛素以来，西他列汀和二甲双胍联合治疗的意义已成为治疗糖尿病的重要策略。在糖尿病患者中，使用西他列汀和二甲双胍等联合治疗来达到理想的血糖水平非常重要，这是对抗糖尿病的另一种手段。
本文回顾了肠促胰岛素的历史、糖尿病的病理生理学以及西他列汀和二甲双胍联合治疗的应用。
实现最佳血糖控制对于避免或至少延迟与糖尿病相关的并发症的进展至关重要。最近，人们已经非常清楚地认识到，单一的抗糖尿病药物治疗往往不能成功地控制血糖。因此，许多 2 型糖尿病患者需要多种联合治疗。使用西他列汀和二甲双胍联合治疗是治疗糖尿病的理想策略。
