Hemker H Coen
Synapse BV, Cardiovasculair Research Instituut Maastricht (CARIM), The Netherlands.
Ned Tijdschr Geneeskd. 2011;155:A2572.
A test is needed of which the score is low in case of haemorrhagic tendency and high in case of thrombotic tendency. Emerging evidence shows that thrombin generation is a promising candidate. Recently it became possible to measure the course in thrombin concentration in clotting blood or blood plasma in an simple way suitable for application in a routine clinical setting. It appears that the amount of thrombin developing in clotting blood or blood plasma is a better measure for thrombotic- or haemorrhagic tendency than any variant of the clotting time and that thrombin generation is a universal test for the effect of antithrombotic drugs.
需要一种测试，在出血倾向时得分低，在血栓形成倾向时得分高。新出现的证据表明，凝血酶生成是一个有前景的候选指标。最近，已经能够以一种适用于常规临床环境的简单方法来测量凝血血液或血浆中凝血酶浓度的变化过程。似乎在凝血血液或血浆中产生的凝血酶量比任何凝血时间变体更能衡量血栓形成或出血倾向，并且凝血酶生成是对抗血栓药物效果的一种通用测试。
