Department of Dermatology, and Pathology, Dr. Behcet Uz Children Hospital, Izmir, Turkey.
J Cutan Med Surg. 2011 Jan-Feb;15(1):1-7. doi: 10.2310/7750.2010.09065.
Tenascin-C is a large extracellular matrix protein that is expressed in the basal membrane zone during embryonic development, tissue repair, and oncogenesis. In vitro studies suggest that proliferating epithelium induces the production of tenascin-C by mesenchymal cells.
Our goal was to compare the expression of tenascin-C in psoriasis with other papulosquamous disorders of the skin in pediatric patients.
The study was conducted on skin biopsy samples of 37 patients with psoriasis or other papulosquamous disorders. Of the 37 skin biopsy samples, 17 (45.9%) were diagnosed as psoriasis and 20 (54.1%) were diagnosed as other papulosquamous disorders histopathologically, and the expression of tenascin-C was evaluated immunohistochemically.
Tenascin-C expression was seen in the dermis of lesional tissues or epidermal keratinocytes in 1 (5.8%) of the 17 biopsy samples diagnosed as psoriasis and 15 (75.0%) of the 20 biopsy samples diagnosed as other papulosquamous disorders (p = .001).
Tenascin-C expression was not found to be a staining characteristic of psoriasis lesions. But the significant staining intensity of the tenascin-C expression in other papulosquamous disorders suggests that tenascin-C expression might be an epiphenomenon in the papulosquamous disorders other than psoriasis immunohistochemically.
Tenascin-C 是一种大型细胞外基质蛋白，在胚胎发育、组织修复和肿瘤发生过程中表达于基底层。体外研究表明，增殖的上皮细胞诱导间充质细胞产生 Tenascin-C。
我们的目标是比较儿童银屑病患者与其他皮肤丘疹鳞屑性疾病中 Tenascin-C 的表达。
对 37 例银屑病或其他皮肤丘疹鳞屑性疾病患者的皮肤活检样本进行了研究。37 例皮肤活检样本中，17 例（45.9%）诊断为银屑病，20 例（54.1%）病理诊断为其他皮肤丘疹鳞屑性疾病，采用免疫组化法评估 Tenascin-C 的表达。
在 17 例诊断为银屑病的活检样本中有 1 例（5.8%）和 20 例诊断为其他皮肤丘疹鳞屑性疾病的活检样本中有 15 例（75.0%）真皮组织的皮损或表皮角朊细胞中可见 Tenascin-C 表达（p=0.001）。
Tenascin-C 的表达不是银屑病皮损的染色特征。但在其他皮肤丘疹鳞屑性疾病中，Tenascin-C 表达的显著染色强度提示 Tenascin-C 的表达可能是除银屑病以外的皮肤丘疹鳞屑性疾病的一种伴随现象。
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