Department of Pharmacology, Istanbul University, Faculty of Pharmacy, 34116, Beyazit, Istanbul, Turkey.
Clin Biochem. 2011 Apr;44(5-6):364-7. doi: 10.1016/j.clinbiochem.2011.01.011. Epub 2011 Feb 1.
The aim of the study was to investigate serum levels of asymmetric dimethylarginine (ADMA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasma levels of 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)) in patients with fibromyalgia.
Twenty-seven patients with fibromyalgia and twenty healthy controls were enrolled in this study. ADMA, TNF-α, IL-6 and 8-iso-PGF(2α) levels were measured by enzyme-linked immunosorbent assay (ELISA).
Serum levels of ADMA and TNF-α and plasma levels 8-iso-PGF(2α) were significantly increased in patients with fibromyalgia compared to controls. However, no significant difference was observed in IL-6 levels between the two groups. ADMA concentrations were positively correlated with TNF-α and 8-iso-PGF(2α) levels in patients with fibromyalgia.
This is the first study reporting that ADMA levels are significantly elevated in patients with fibromyalgia in association with increased 8-iso-PGF(2α) and TNF-α concentrations. Thereby, ADMA could be suggested as a reliable marker of endothelial dysfunction in patients with fibromyalgia.
本研究旨在探讨纤维肌痛患者血清不对称二甲基精氨酸（ADMA）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和血浆 8-异前列腺素 F2α（8-iso-PGF2α）水平。
本研究纳入了 27 例纤维肌痛患者和 20 名健康对照者。采用酶联免疫吸附试验（ELISA）测定 ADMA、TNF-α、IL-6 和 8-iso-PGF2α 水平。
与对照组相比，纤维肌痛患者血清 ADMA 和 TNF-α水平以及血浆 8-iso-PGF2α 水平显著升高。然而，两组间 IL-6 水平无显著差异。纤维肌痛患者 ADMA 浓度与 TNF-α和 8-iso-PGF2α 水平呈正相关。
这是首项研究报道纤维肌痛患者 ADMA 水平显著升高，并伴有 8-iso-PGF2α 和 TNF-α浓度升高。因此，ADMA 可作为纤维肌痛患者内皮功能障碍的可靠标志物。
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