CAS Key Laboratory of Soft Matter Chemistry, Lab of Functional Membranes, School of Chemistry and Material Science, University of Science and Technology of China, Hefei 230026, PR China.
Int J Pharm. 2011 Apr 15;408(1-2):39-49. doi: 10.1016/j.ijpharm.2011.01.046. Epub 2011 Feb 1.
The clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) (such as sodium salicylate (NaSA)) for the treatment of chronic arthritis is limited due to the adverse effects and patient non-compliance. In order to solve these problems, anion exchange hollow fiber membranes (AEHFMs) are proposed for the first time here as potential drug carriers. Brominated poly(2,6-dimethyl-1,4-phenylene oxide) (BPPO) is used as the starting membrane material. In-situ sol-gel process of γ-methacryloxypropyl trimethoxysilane (γ-MPS) in BPPO matrix is operated so as to enhance the membranes' thermal and dimensional stability. The performances of the membranes in controlled release of the drug (NaSA as the model drug) are improved accordingly. Loading and release experiments illustrate that the hybrid AEHFM can bind salicylate (SA⁻) at a high loading efficiency (28.4%), and the retention of the drug on the membrane matrix is significantly prolonged (drug released in 7 days under physiological condition: 51.9%, neglecting the drug bound by protein). Meanwhile, the membrane is biocompatible and can support the adherence, growth, and survival of human cells. Overall, the prepared AEHFM is a promising scaffolding material for drug delivery and tissue engineering.
非甾体抗炎药（NSAIDs）（如水杨酸钠（NaSA））在慢性关节炎治疗中的临床应用受到限制，这是由于其不良反应和患者不依从性。为了解决这些问题，首次提出阴离子交换中空纤维膜（AEHFMs）作为潜在的药物载体。溴化聚（2,6-二甲基-1,4-亚苯基氧化物）（BPPO）用作起始膜材料。在 BPPO 基质中进行γ-甲基丙烯酰氧基丙基三甲氧基硅烷（γ-MPS）的原位溶胶-凝胶过程，以提高膜的热和尺寸稳定性。相应地，改善了药物（以 NaSA 为模型药物）的控释性能。负载和释放实验表明，该杂化 AEHFM 可以以高负载效率（28.4%）结合水杨酸根（SA⁻），并且药物在膜基质上的保留时间显著延长（在生理条件下 7 天内释放的药物：51.9%，忽略与蛋白质结合的药物）。同时，该膜具有生物相容性，能够支持人细胞的黏附、生长和存活。总的来说，所制备的 AEHFM 是一种很有前途的药物输送和组织工程支架材料。
