Department of Obstetrics and Gynecology, University of Melbourne, Parkville, VIC, Australia.
Am J Obstet Gynecol. 2011 May;204(5):415.e1-415.e12. doi: 10.1016/j.ajog.2010.12.005. Epub 2011 Feb 3.
The purpose of this study was to investigate whether birth of a small-for-gestational-age (SGA) baby (birthweight, <10th percentile) is preceded by altered maternal serum cytokine profiles at early pregnancy, compared with control babies (birthweight, 30-80th percentile).
A retrospective case-control study of maternal serum collected prospectively across 7-10 weeks of gestation from women attending their first prenatal visit (SGA, 57 cases; control subjects, 71 cases selected retrospectively). Serum concentrations of 27 cytokines were measured in each sample and analyzed by 2-way analysis of variance and nonparametric tests. Logistic regression was used for predictive modeling.
Of 21 detectable cytokines/chemokines, 14 analytes varied significantly (P ≤ .030) among those women who were destined to deliver an SGA baby, when compared with control subjects. Of the cytokines that varied in association with SGA, interferon-γ concentrations increased, and major proinflammatory (interleukin [IL]-2, -7, -12) and antiinflammatory (IL-1 receptor antagonist, -4, -10, -13) cytokine concentrations decreased. Eotaxin and macrophage inflammatory protein-1α were higher; monocyte chemoattractant protein-1 and IL-8 were lower.
SGA births may be preceded by altered immune cytokine profiles at 7-10 weeks of gestation.
本研究旨在探讨与对照组婴儿（出生体重为 30-80 百分位）相比，小胎龄儿（出生体重，<第 10 百分位）的母亲在妊娠早期是否存在血清细胞因子谱改变。
一项回顾性病例对照研究，前瞻性收集了 7-10 周妊娠首次产前检查的妇女的血清（SGA，57 例；对照组，71 例为回顾性选择）。对每个样本中的 27 种细胞因子浓度进行了测量，并通过双因素方差分析和非参数检验进行了分析。采用逻辑回归进行预测建模。
在 21 种可检测的细胞因子/趋化因子中，与对照组相比，14 种分析物在注定要分娩 SGA 婴儿的女性中差异显著（P≤0.030）。与 SGA 相关的细胞因子中，干扰素-γ浓度升高，主要促炎（白细胞介素[IL]-2、-7、-12）和抗炎（IL-1 受体拮抗剂、-4、-10、-13）细胞因子浓度降低。嗜酸性粒细胞趋化因子和巨噬细胞炎性蛋白-1α升高；单核细胞趋化蛋白-1 和 IL-8 降低。
SGA 出生可能在妊娠 7-10 周时存在改变的免疫细胞因子谱。
