Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 450001 Zhengzhou, China.
Lung Cancer. 2011 Aug;73(2):153-7. doi: 10.1016/j.lungcan.2010.12.012. Epub 2011 Feb 2.
N-acetyltransferase 2 (NAT2) gene encodes a key enzyme involved in the metabolism of xenobiotics and whose polymorphisms have been related to individual susceptibility to several malignancies. Although many epidemiological studies have explored the association between NAT2 genetic polymorphism and lung cancer risk, the results remain controversial. In order to assess the overall relationship between NAT2 polymorphism and lung cancer risk, we performed a meta-analysis including 3945 lung cancer cases and 6085 controls from 19 published studies which were selected from 29 articles identified by a search of PubMed up to 1st June 2010. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association. No significant association was found in overall analysis (OR=1.02, 95% CI=0.90-1.16, P=0.01 for heterogeneity) and in subgroup analyses by ethnicity, sex, histological type, smoking status and study design. In conclusion, this meta-analysis found little evidence of an association between the NAT2 polymorphism and the risk of lung cancer.
N-乙酰基转移酶 2（NAT2）基因编码一种参与外源物质代谢的关键酶，其多态性与个体易患多种恶性肿瘤有关。尽管许多流行病学研究探讨了 NAT2 基因多态性与肺癌风险之间的关系，但结果仍存在争议。为了评估 NAT2 多态性与肺癌风险之间的总体关系，我们进行了一项荟萃分析，纳入了 19 项研究中的 3945 例肺癌病例和 6085 例对照，这些研究是从 2010 年 6 月 1 日之前在 PubMed 上搜索到的 29 篇文章中选择的。使用粗比值比（OR）和 95%置信区间（CI）来评估相关性。总体分析（OR=1.02，95%CI=0.90-1.16，P=0.01 用于异质性）和按种族、性别、组织学类型、吸烟状况和研究设计进行的亚组分析均未发现显著相关性。综上所述，这项荟萃分析几乎没有发现 NAT2 多态性与肺癌风险之间存在关联的证据。
