Amireche N, Petit J-S, Bankole E, Fournet-Fayard A, Appriou M, Leon A
Unité de réanimation polyvalente, hôpital Maison-Blanche, CHU de Reims, 45 rue Cognacq-Jay, Reims cedex, France.
Ann Fr Anesth Reanim. 2011 Feb;30(2):150-2. doi: 10.1016/j.annfar.2010.11.022. Epub 2011 Feb 2.
Disulfiram is commonly used in the treatment of alcohol dependence. It induces aversive symptoms after alcohol ingestion: the "acetaldehyde syndrome". Most often "acetaldehyde syndrome" is moderate but severe life-threatening symptoms may occur in specific circumstances. We report the case of a serious "acetaldehyde syndrome" with shock compounded by the initial administration of dopamine. Discussion clarifies the pathophysiology and develops the therapeutic management.
双硫仑常用于治疗酒精依赖。饮酒后它会引发厌恶症状:即“乙醛综合征”。多数情况下“乙醛综合征”症状较轻,但在特定情况下可能会出现严重的危及生命的症状。我们报告了一例严重的“乙醛综合征”并伴有休克的病例,该病例因最初使用多巴胺而加重。讨论阐明了其病理生理学并提出了治疗处理方法。