分析肺部炎症 PET 研究中 2-[氟-18]-氟代-2-脱氧-D-葡萄糖摄取动力学。
Analysis of 2-[Fluorine-18]-Fluoro-2-deoxy-D-glucose uptake kinetics in PET studies of pulmonary inflammation.
机构信息
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, 02114, USA.
出版信息
Acad Radiol. 2011 Apr;18(4):418-23. doi: 10.1016/j.acra.2010.11.019. Epub 2011 Feb 3.
Abstract
Dynamic positron emission tomography (PET) imaging of the lung using the radiotracer 2-[fluorine-18]-fluoro-2-deoxy-D-glucose ((18)F-FDG) is an emerging method to assess noninvasively the metabolic activity of pulmonary inflammatory cells. Nevertheless, because of the distinct functional and structural characteristics of inflamed lung tissue standard methods of (18)F-FDG analysis can be substantially limited and there is no consensus about the best method for quantification of the (18)F-FDG signal for acute or chronic inflammatory lung diseases. This article gives an overview on recent advances in quantitative analysis of (18)F-FDG uptake kinetics in non-neoplastic inflamed lung tissue.
摘要
使用放射性示踪剂 2-[氟-18]-氟-2-脱氧-D-葡萄糖 ((18)F-FDG) 进行动态正电子发射断层扫描 (PET) 成像，是一种新兴的方法，可以非侵入性地评估肺部炎症细胞的代谢活性。然而，由于炎症性肺组织的功能和结构特征明显不同，标准的 (18)F-FDG 分析方法可能会受到很大限制，并且对于急性或慢性炎症性肺病的 (18)F-FDG 信号定量方法也没有共识。本文综述了非肿瘤性炎症性肺组织中 (18)F-FDG 摄取动力学的定量分析的最新进展。
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