University of Athens, Athens, Greece.
Blood. 2011 May 5;117(18):4701-5. doi: 10.1182/blood-2010-10-299529. Epub 2011 Feb 3.
A panel of members of the 2009 International Myeloma Workshop developed guidelines for standard investigative workup of patients with suspected multiple myeloma. Both serum and urine should be assessed for monoclonal protein. Measurement of monoclonal protein both by densitometer tracing and/by nephelometric quantitation is recommended, and immunofixation is required for confirmation. The serum-free light chain assay is recommended in all newly diagnosed patients with plasma cell dyscrasias. Bone marrow aspiration and/or biopsy along with demonstration of clonality of plasma cells are necessary. Serum β(2)-microglobulin, albumin, and lactate dehydrogenase are necessary for prognostic purposes. Standard metaphase cytogenetics and fluorescent in situ hybridization for 17p, t(4;14), and t(14;16) are recommended. The skeletal survey remains the standard method for imaging screening, but magnetic resonance imaging frequently provides valuable diagnostic and prognostic information. Most of these tests are repeated during follow-up or at relapse.
一个由 2009 年国际骨髓瘤工作组的成员组成的小组制定了疑似多发性骨髓瘤患者标准调查的指南。血清和尿液都应评估单克隆蛋白。建议通过比浊法和/或散射比浊法定量测量单克隆蛋白，免疫固定电泳用于确认。浆细胞异常的所有新诊断患者都推荐进行血清游离轻链检测。骨髓抽吸和/或活检以及浆细胞克隆性的证明是必要的。血清β(2)-微球蛋白、白蛋白和乳酸脱氢酶是预后所必需的。建议进行标准中期细胞遗传学和荧光原位杂交，以检测 17p、t(4;14)和 t(14;16)。骨骼检查仍然是成像筛查的标准方法，但磁共振成像经常提供有价值的诊断和预后信息。在随访或复发时，大多数这些测试都会重复进行。
