Department of Neurology, CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, France.
Stroke. 2011 Mar;42(3):e27-30. doi: 10.1161/STROKEAHA.110.594218. Epub 2011 Feb 3.
The purpose of this study was to report the detection of infarcts of the cerebral cortex in a patient with cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) using high-resolution postmortem 7-T MRI in association with pathological examination.
Whole brain high-resolution MRI data were obtained postmortem at 7 T in a 53-year-old patient with CADASIL. These MRI data were used to guide the neuropathological examination of the cortex.
Combined with neuropathology, MRI allowed the delineation of intracortical infarcts confirmed by histological examination in this case. These lesions were not visible on the last in vivo MRI obtained at 1.5 T and were difficult to detect on neuropathological examination only.
Postmortem high-resolution MRI may help to detect intracortical infarcts in CADASIL and possibly in other small vessel diseases of the brain.
本研究旨在报告一例脑常染色体显性动脉病伴皮质下梗死和白质脑病（CADASIL）患者，通过高分辨率的 7-T 磁共振成像（MRI）结合病理学检查，检测到大脑皮层梗死。
在一例 53 岁的 CADASIL 患者死后，我们在 7T 上获得了全脑高分辨率 MRI 数据。这些 MRI 数据用于指导皮层的神经病理学检查。
结合神经病理学，MRI 允许对该病例的皮层内梗死进行描绘，这些病变在最后一次在 1.5T 进行的体内 MRI 上不可见，仅在神经病理学检查中难以发现。
死后高分辨率 MRI 可能有助于检测 CADASIL 中的皮层内梗死，也可能有助于检测其他大脑小血管疾病中的皮层内梗死。
