Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, China.
Int J Gynecol Pathol. 2011 Mar;30(2):145-50. doi: 10.1097/PGP.0b013e3181ffd2f7.
Astrocyte elevated gene-1 (AEG-1) plays an important role in tumor progression including transformation, evasion of apoptosis, invasion, metastasis, and chemoresistance. However, the expression of AEG-1 in ovarian carcinoma and its significance are still unclear. The aim of this study was to examine the expression of AEG-1 in ovarian carcinoma. Immunohistochemistry was performed to determine the expression of AEG-1 in 81 ovarian carcinoma specimens. The correlation of AEG-1 expression with clinicopathological parameters was assessed using χ2 analysis. Patient survival was analyzed using the Kaplan-Meier and log-rank tests. Cox regression was used for the multivariate analysis of prognostic factors. High expression of AEG-1 was detected in 66.67% of the ovarian carcinomas and was significantly associated with the International Federation of Gynecology and Obstetrics stage, histological grade, presence of residual tumor after primary surgery, and tumor recurrence. Patients with high AEG-1 expression had significantly poorer overall survival and disease-free survival (both P<0.001) when compared with patients with low expression of AEG-1. The multivariate Cox analysis showed that AEG-1 was an independent factor for both overall survival and disease-free survival (both P<0.001). These results showed that high AEG-1 expression was associated with progression and prognosis of ovarian carcinoma.
星形细胞上调基因-1（AEG-1）在肿瘤进展中发挥重要作用，包括转化、逃避凋亡、侵袭、转移和化疗耐药。然而，AEG-1 在卵巢癌中的表达及其意义尚不清楚。本研究旨在探讨 AEG-1 在卵巢癌中的表达。采用免疫组织化学法检测 81 例卵巢癌标本中 AEG-1 的表达。采用 χ2 分析评估 AEG-1 表达与临床病理参数的相关性。采用 Kaplan-Meier 和对数秩检验分析患者生存情况。采用 Cox 回归进行预后因素的多因素分析。结果发现，66.67%的卵巢癌中检测到 AEG-1 高表达，AEG-1 表达与国际妇产科联合会（FIGO）分期、组织学分级、初次手术残留肿瘤、肿瘤复发显著相关。AEG-1 高表达患者的总生存和无病生存均显著低于 AEG-1 低表达患者（均 P<0.001）。多因素 Cox 分析显示，AEG-1 是总生存和无病生存的独立预后因素（均 P<0.001）。这些结果表明，AEG-1 高表达与卵巢癌的进展和预后相关。
