Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.
Int J Gynecol Pathol. 2011 Mar;30(2):117-20. doi: 10.1097/PGP.0b013e3181f5ce68.
We report the clinicopathological and molecular characteristics of a rare uterine endometrioid carcinoma with a nongestational trophoblastic neoplastic component that was composed of both choriocarcinoma and epithelioid trophoblastic tumor. Molecular genetic analysis showed a clonal evolution from endometrioid carcinoma to trophoblastic tumor. The findings from this case have both diagnostic and biological implications that may inspire future studies on the pathogenic mechanisms by which cancer stem cells assume aberrant differentiation programs and the molecular switch(es) that initiates trophoblastic differentiation in adult tumor tissues.
我们报告了一例罕见的具有非妊娠性滋养细胞肿瘤成分的子宫子宫内膜样癌的临床病理和分子特征，该肿瘤由绒毛膜癌和上皮样滋养细胞瘤组成。分子遗传学分析显示，从子宫内膜样癌到滋养细胞瘤存在克隆进化。该病例的发现具有诊断和生物学意义，可能激发未来对癌症干细胞通过何种异常分化程序以及在成人肿瘤组织中启动滋养细胞分化的分子开关的研究。
