Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA.
J Clin Exp Neuropsychol. 2011 Jun;33(5):538-47. doi: 10.1080/13803395.2010.537253. Epub 2011 Feb 2.
Traumatic brain injury often negatively impacts episodic memory; however, studies of the neural substrates of this impairment have been limited. In this study, both encoding and recognition of visually presented stimuli were examined with functional magnetic resonance imaging. Twelve adults with chronic complicated mild, moderate, and severe injuries were compared with a matched group of 12 controls. Behavioral task performance did not differentiate the groups. During neuroimaging, however, the group of individuals with traumatic brain injury exhibited increased activation, as well as increased bilaterality and dispersion as compared to controls. Findings are discussed in terms of increased resource recruitment.
创伤性脑损伤常对情景记忆产生负面影响；然而，对这种损伤的神经基础的研究一直很有限。在这项研究中，使用功能磁共振成像检查了视觉呈现刺激的编码和识别。将 12 名患有慢性复杂轻度、中度和重度损伤的成年人与 12 名匹配的对照组进行了比较。行为任务表现并未使这些组产生差异。然而，在神经影像学检查中，与对照组相比，创伤性脑损伤患者组表现出更高的激活程度，以及更高的双侧性和分散性。研究结果从资源招募增加的角度进行了讨论。
