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儿童良性小脑毛细胞型星形细胞瘤

Benign cerebellar pilocytic astrocytomas in children.

作者信息

Bilginer Burcak, Narin Firat, Oguz Kader Karli, Uzun Sennur, Soylemezoglu Figen, Akalan Nejat

机构信息

Hacettepe University, School of Medicine, Department of Neurosurgery, Ankara, Turkey.

出版信息

Turk Neurosurg. 2011 Jan;21(1):22-6.

Abstract

AIM

Cerebellar astrocytomas are benign tumors of the central nervous system. They represent 10% of all pediatric intracranial brain tumors and 30% of all pediatric posterior fossa tumors especially in the first two decades of life.

MATERIAL AND METHODS

We reviewed the medical records of patients; age at the time of surgery, pre- and post operative magnetic resonance imaging (MRI), localisation of the tumor, hydrocephalus, surgical approach, pre- and post operative neurological status, post operative adjuvant therapy and outcome were documented.

RESULTS

The male to female ratio was 20/11. Age at the time of evaluation ranged from 3 to 23 years. Age at the time of surgery ranged from 1 to 18 years. Follow-up duration after surgery was 1-12 years. 55% of these tumors were located at the cerebellar vermis and 45% were at the cerebellar hemispheres. Complete surgical resection was done in 74% of these patients. 5 patients had a second operation because of residual tumor. Ventriculoperitoneal shunt insertion was performed in 3 of 31 patients because of symptomatic hydrocephalus and 1 patient had an endoscopic third ventriculostomy pre-operatively. 90% of these patients had no neurological sequelae at follow-up evaluation.

CONCLUSION

Cerebellar astrocytomas are benign tumors where total resection is possible in the majority of cases with an excellent outcome.

摘要

目的

小脑星形细胞瘤是中枢神经系统的良性肿瘤。它们占所有儿童颅内脑肿瘤的10%,占所有儿童后颅窝肿瘤的30%,尤其是在生命的前二十年。

材料与方法

我们回顾了患者的病历;记录了手术时的年龄、术前和术后的磁共振成像(MRI)、肿瘤的位置、脑积水情况、手术入路、术前和术后的神经状态、术后辅助治疗及结果。

结果

男女比例为20/11。评估时的年龄范围为3至23岁。手术时的年龄范围为1至18岁。术后随访时间为1至12年。这些肿瘤中55%位于小脑蚓部,45%位于小脑半球。74%的患者进行了完整的手术切除。5例患者因肿瘤残留进行了二次手术。31例患者中有3例因症状性脑积水进行了脑室腹腔分流术,1例患者术前进行了内镜下第三脑室造瘘术。90%的患者在随访评估时无神经后遗症。

结论

小脑星形细胞瘤是良性肿瘤,大多数情况下可以进行全切除,预后良好。

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