Ucar Tanju, Kazan Saim, Turgut Umut, Samanci Nehir Karaman
Akdeniz University, Faculty of Medicine, Department of Neurosurgery, Antalya, Turkey.
Turk Neurosurg. 2011 Jan;21(1):59-65.
Spasticity is associated with various neurological conditions. Intrathecal baclofen (ITB) is one of the popular treatments for severe spasticity. In this paper we present our experience in treating 30 patients with both spinal and supraspinal spasticity with chronic infusion of Baclofen to evaluate the long term efficacy of this treatment on spasticity, disability and pain, and to evaluate the side effects of intrathecal Baclofen.
The medical records of 30 patients who underwent baclofen pump placement from 2000 to 2010 under Department of Neurosurgery at the University of Akdeniz at Antalya/Turkey, were reviewed. All study subjects had diffuse chronic, severe, and generalized spasticity (Ashworth score ≥ 3), and had shown inadequate response to various oral antispastic drugs including baclofen. All patients were evaluated by means of the Ashworth score, spasm frequency, Barthel index, Rankin scales and VAS.
Spasticity and spasm frequency and pain scores were clinically and statistically decreased in all patients.
ITB therapy increases the quality of lifestyle and functional independence by reducing not only cerebral but also spinal related spasticity in appropriately selected cases.
痉挛与多种神经系统疾病相关。鞘内注射巴氯芬（ITB）是治疗严重痉挛的常用方法之一。在本文中，我们介绍了对30例伴有脊髓性和脊髓以上部位痉挛的患者进行巴氯芬长期输注治疗的经验，以评估该治疗对痉挛、残疾和疼痛的长期疗效，并评估鞘内注射巴氯芬的副作用。
回顾了2000年至2010年在土耳其安塔利亚阿克德尼兹大学神经外科接受巴氯芬泵植入的30例患者的病历。所有研究对象均患有弥漫性慢性、严重和全身性痉挛（Ashworth评分≥3），且对包括巴氯芬在内各种口服抗痉挛药物反应不佳。所有患者均通过Ashworth评分、痉挛频率、Barthel指数、Rankin量表和视觉模拟评分法（VAS）进行评估。
所有患者的痉挛、痉挛频率和疼痛评分在临床和统计学上均有所下降。
在适当选择的病例中，ITB治疗不仅可减轻与大脑相关的痉挛，还可减轻与脊髓相关的痉挛，从而提高生活质量和功能独立性。
