Kanitsap Nonglak, Warnnissorn Naree
Division of Hematology, Department of Medicine, Faculty of Medicine, Thammasat University, Rungsit Campus, Pathumtani, Thailand.
J Med Assoc Thai. 2010 Dec;93 Suppl 7:S294-8.
Extranodal Nasal NK/T cell lymphoma, relatively uncommon type of non-Hodgkin's lymphoma, is highly aggressive disease with poor outcomes. Early stage disease may response to radiotherapy alone. However the treatments are usually chemotherapy and radiotherapy combination and late stage disease may not response to any available therapy. We reported a 45-year-old woman with extranodal nasal type NK/T cell lymphoma. The patient presented with chronic nasal stuffiness and mucous bloody discharge. The nasal mass is extensively involved periorbital and sinonasal soft tissue. Due to the extensively involved of tumor, combination chemotherapy was used to induce response. This patient was involved by complicated infection and palatal ulcer with likely perforation. The salvage chemotherapy was given and the treatment of NK/T cell lymphoma from other reports and literatures were reviewed.
结外鼻型NK/T细胞淋巴瘤是一种相对罕见的非霍奇金淋巴瘤，是一种侵袭性很强、预后较差的疾病。早期疾病可能仅对放疗有反应。然而，治疗通常是化疗和放疗联合使用，晚期疾病可能对任何现有治疗均无反应。我们报告了一名45岁患有结外鼻型NK/T细胞淋巴瘤的女性。患者表现为慢性鼻塞和黏液血性分泌物。鼻腔肿物广泛累及眶周和鼻窦软组织。由于肿瘤广泛累及，采用联合化疗诱导缓解。该患者合并复杂感染和腭部溃疡，可能发生穿孔。给予挽救性化疗，并回顾了其他报道和文献中关于NK/T细胞淋巴瘤的治疗情况。
