阿立哌唑治疗孤独症相关的易激惹。
Aripiprazole for the treatment of irritability associated with autism.
机构信息
The Ohio State University, Nisonger Center, 1581 Dodd Drive, Columbus, OH 43210, USA.
出版信息
Expert Opin Pharmacother. 2011 Mar;12(4):635-40. doi: 10.1517/14656566.2011.557661. Epub 2011 Feb 6.
Abstract
INTRODUCTION
Irritability (including tantrums, aggression and moodiness) is often associated with autistic disorder. Children with autism are frequently prescribed atypical antipsychotic medications for these behaviors. Although multiple agents have been found to be effective, the safety and tolerability of each antipsychotic may be the determining factor in its selection.
AREAS COVERED
The pharmacokinetics, pharmacodynamics, safety and efficacy data on aripiprazole for the treatment of irritability associated with autism are discussed. Knowledge of the mechanism of action, advantages and disadvantages relative to other atypical antipsychotics, and an appreciation of the efficacy of aripiprazole when used to treat irritability in autism is also explored in this paper.
EXPERT OPINION
Aripiprazole may have a more favorable side-effect profile than another commonly prescribed medication, risperidone, because of its unique mechanism of action. It seems to be effective in treating irritability associated with autism, but more research is needed.
摘要
简介
烦躁（包括发脾气、攻击行为和情绪不稳）常与自闭症有关。自闭症儿童常因这些行为而被开具非典型抗精神病药物。虽然已经发现多种药物对此有效，但每种抗精神病药物的安全性和耐受性可能是选择的决定因素。
涵盖领域
本文讨论了阿立哌唑治疗自闭症相关烦躁的药代动力学、药效学、安全性和疗效数据。本文还探讨了作用机制、与其他非典型抗精神病药物相比的优缺点的知识，以及阿立哌唑治疗自闭症烦躁的疗效。
专家意见
由于其独特的作用机制，阿立哌唑的副作用谱可能比另一种常用药物利培酮更有利。它似乎对治疗自闭症相关的烦躁有效，但还需要更多的研究。
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Safety and tolerability of aripiprazole in the treatment of irritability associated with autistic disorder in pediatric subjects (6-17 years old):results from a pooled analysis of 2 studies.阿立哌唑治疗儿科患者（6至17岁）自闭症谱系障碍相关易激惹症状的安全性和耐受性：两项研究的汇总分析结果
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Line-item analysis of the Aberrant Behavior Checklist: results from two studies of aripiprazole in the treatment of irritability associated with autistic disorder.异常行为检查表的逐行分析：阿立哌唑治疗孤独症谱系障碍相关易激惹两项研究的结果
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