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院外心脏骤停后不受控制的器官捐献:英国解决器官捐献者短缺的潜在方法?

Uncontrolled organ donation following prehospital cardiac arrest: a potential solution to the shortage of organ donors in the United Kingdom?

机构信息

Department of Liver Transplantation, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.

出版信息

Transpl Int. 2011 May;24(5):477-81. doi: 10.1111/j.1432-2277.2011.01230.x. Epub 2011 Feb 5.

DOI:10.1111/j.1432-2277.2011.01230.x
PMID:21294790
Abstract

Uncontrolled donation after cardiac death (DCD) could increase the donor pool in the UK. Air ambulance (AA) teams may be well placed to recruit these donors. They cover large geographical areas, have short transfer times and tasked predominantly to life-threatening cases. The potential to recruit from this pool of donors was reviewed. Seventy-five month activity of an AA unit was analysed identifying patients who entered prehospital cardiac arrest (PHCA). Patients over 70 years of age were excluded as were those whose cardiac arrest was unwitnessed. A minimum potential donor pool was estimated based upon patients dying of medical causes. Rates of bystander resuscitation, mechanism of death and patient demographic data were observed. During 10,022 missions 534 patients entered PHCA. A total of 106 patients met inclusion criteria. There were 12 paediatric cases; 39 cases of 17-50 year olds and 55 cases of 50-70 year olds. Medical and traumatic causes of death accounted for 60 and 46 cases respectively. Bystander resuscitation efforts were provided in 47% of cases. A regional AA could contribute to a national uncontrolled DCD programme. Given that there are 31 AA's in England and Wales, we estimate that there could be a minimum of 300 additional potential donors annually.

摘要

心脏死亡后不受控制的捐献(DCD)可以增加英国的供体库。空中救护(AA)团队可能非常适合招募这些供体。他们覆盖了大片的地理区域,转移时间短,主要任务是处理危及生命的病例。因此,对从这些供体池中招募的可能性进行了审查。分析了一个 AA 单位 75 个月的活动,确定了进入院前心脏骤停(PHCA)的患者。排除了 70 岁以上的患者以及那些心脏骤停没有目击者的患者。根据死于医疗原因的患者,估计了一个潜在的最小供体库。观察了旁观者复苏的比例、死亡机制和患者人口统计学数据。在 10022 次任务中,有 534 名患者进入 PHCA。共有 106 名患者符合纳入标准。其中有 12 例儿科病例;39 例年龄在 17-50 岁之间,55 例年龄在 50-70 岁之间。医疗和创伤性死亡原因分别占 60%和 46%。47%的病例提供了旁观者复苏。一个地区性的 AA 可以为国家不受控制的 DCD 计划做出贡献。考虑到英格兰和威尔士有 31 个 AA,我们估计每年可能至少有 300 名额外的潜在供体。

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引用本文的文献

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An increased potential for organ donors may be found among patients with out-of-hospital cardiac arrest.在院外心脏骤停患者中可能发现更多的潜在器官捐献者。
Scand J Trauma Resusc Emerg Med. 2022 Aug 17;30(1):50. doi: 10.1186/s13049-022-01037-x.
2
Potential of Donation After Unexpected Circulatory Death Programs Defined by Their Demographic Characteristics.根据人口统计学特征定义的意外循环性死亡后捐赠项目的潜力。
Transplant Direct. 2021 Dec 23;8(1):e1263. doi: 10.1097/TXD.0000000000001263. eCollection 2022 Jan.
3
Protocols for uncontrolled donation after circulatory death: a systematic review of international guidelines, practices and transplant outcomes.
《循环死亡后未控制供体捐献的方案:国际指南、实践和移植结局的系统评价》。
Crit Care. 2015 Jun 24;19(1):268. doi: 10.1186/s13054-015-0985-7.
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Uncontrolled donors with controlled reperfusion after sixty minutes of asystole: a novel reliable resource for kidney transplantation.心脏停搏 60 分钟后控制性再灌注的不受控制供者:肾脏移植的一种新型可靠资源。
PLoS One. 2013 May 30;8(5):e64209. doi: 10.1371/journal.pone.0064209. Print 2013.
5
Donation after cardio-circulatory death liver transplantation.心跳呼吸停止后捐献的肝脏移植。
World J Gastroenterol. 2012 Sep 7;18(33):4491-506. doi: 10.3748/wjg.v18.i33.4491.