Lantz M, Malik S, Slevin M L, Olsson I
Division of Hematology, Department of Medicine, Lund, Sweden.
Cytokine. 1990 Nov;2(6):402-6. doi: 10.1016/1043-4666(90)90048-x.
Serum samples from cancer patients receiving intravenous infusions of recombinant tumor necrosis factor (rTNF) and recombinant interferon-gamma (rIFN-gamma) were analyzed for TNF and the TNF-binding protein (TNF-BP). TNF-BP is a soluble fragment of the transmembrane TNF receptor with antagonistic effects to TNF and is released by proteolytic cleavage of the receptor. During a 60-min infusion of rTNF, peak serum levels of rTNF were observed after 30 to 60 min and a transient increase of circulating TNF-BP was observed with peak levels between 30 and 120 min. Injection of IFN-gamma alone did not affect the levels of TNF and TNF-BP. Thus administration of rTNF leads to release into the circulation of TNF-BP, which may modulate both systemic and local effects of TNF and influence its therapeutic efficacy.
对接受重组肿瘤坏死因子（rTNF）和重组干扰素-γ（rIFN-γ）静脉输注的癌症患者的血清样本进行了TNF和TNF结合蛋白（TNF-BP）分析。TNF-BP是跨膜TNF受体的可溶性片段，对TNF具有拮抗作用，由受体的蛋白水解裂解释放。在rTNF 60分钟的输注过程中，30至60分钟后观察到rTNF的血清峰值水平，同时观察到循环TNF-BP短暂升高，峰值水平在30至120分钟之间。单独注射IFN-γ不影响TNF和TNF-BP的水平。因此，rTNF的给药导致TNF-BP释放到循环中，这可能调节TNF的全身和局部作用并影响其治疗效果。
