FR 8.3 Biosciences, Laboratory of EpiGenetics, Saarland University, Saarbrücken, Germany.
Cell Stem Cell. 2011 Feb 4;8(2):121-2. doi: 10.1016/j.stem.2011.01.009.
DNA and chromatin-modifying enzymes establish an ESC/iPSC-specific epigenomic landscape that is linked to a network of pluripotency genes and influences differentiation potential. In this issue of Cell Stem Cell, Koh et al. (2011) highlight Tet1 and Tet2 as key players in this network of coordinated genetic and epigenetic control.
DNA 和染色质修饰酶建立了一个 ESC/iPSC 特异性的表观基因组景观，它与一个多能性基因网络有关，并影响分化潜能。在本期《Cell Stem Cell》中，Koh 等人（2011）强调 Tet1 和 Tet2 是这个协调的遗传和表观遗传控制网络中的关键参与者。
