抗着丝点抗体参与干扰卵母细胞减数分裂和胚胎卵裂。
Involvement of anticentromere antibody in interference with oocyte meiosis and embryo cleavage.
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
出版信息
Fertil Steril. 2011 Jun 30;95(8):2729-31. doi: 10.1016/j.fertnstert.2011.01.013. Epub 2011 Feb 4.
The aim of this study was to investigate the clinical significance of anticentromere antibody (ACA) among types of antinuclear antibody (ANA) in the properties of oocytes retrieved from infertile women. The rate of metaphase II oocytes or embryo cleavage was significantly decreased in patients with positive ACA compared with patients with negative ACA, suggesting that ACA is an essential marker for flawed oocytes in infertile women with any type of ANA.
本研究旨在探讨抗着丝点抗体（ACA）在不孕妇女卵母细胞中的核抗体（ANA）类型中的临床意义。与 ACA 阴性患者相比，ACA 阳性患者的中期 II 卵母细胞或胚胎分裂率显著降低，这表明 ACA 是任何类型 ANA 的不孕妇女有缺陷卵母细胞的重要标志物。
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