Department of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, Greece.
Assisted Conception Unit, 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, Greece.
Int J Mol Sci. 2019 Feb 19;20(4):892. doi: 10.3390/ijms20040892.
The role of autoantibodies in in vitro fertilization (IVF) has been discussed for almost three decades. Nonetheless, studies are still scarce and widely controversial. The aim of this study is to provide a comprehensive systematic review on the possible complications associated to autoantibodies (AA) impeding the chances of a successful IVF cycle. An Embase, PubMed/Medline and Cochrane Central Database search was performed on 1 December 2018, from 2006 until that date. From the 598 articles yielded in the search only 44 relevant articles ultimately fulfilled the inclusion criteria and were qualitatively analyzed. Five subsets of results were identified, namely, thyroid related AA, anti-phospholipid antibodies, anti-nuclear antibodies, AA affecting the reproductive system and AA related to celiac disease. It may be implied that the majority of auto-antibodies exert a statistically significant effect on miscarriage rates, whereas the effects on clinical pregnancy and live birth rates differ according to the type of auto-antibodies. While significant research is performed in the field, the quality of evidence provided is still low. The conduction of well-designed prospective cohort studies is an absolute necessity in order to define the impact of the different types of autoantibodies on IVF outcome.
自身抗体在体外受精（IVF）中的作用已经讨论了近三十年。尽管如此，相关研究仍然很少，且存在广泛争议。本研究旨在对与自身抗体（AA）相关的可能并发症进行全面的系统综述，这些并发症可能会影响 IVF 周期的成功率。我们于 2018 年 12 月 1 日对 Embase、PubMed/Medline 和 Cochrane Central Database 进行了检索，检索时间范围为 2006 年至该日期。在检索中得到的 598 篇文章中，仅有 44 篇相关文章最终符合纳入标准并进行了定性分析。确定了五个结果子集，即甲状腺相关 AA、抗磷脂抗体、抗核抗体、影响生殖系统的 AA 和与乳糜泻相关的 AA。可能意味着大多数自身抗体对流产率有统计学意义的影响，而对临床妊娠率和活产率的影响则根据自身抗体的类型而有所不同。虽然该领域进行了大量研究，但提供的证据质量仍然较低。为了确定不同类型的自身抗体对 IVF 结局的影响，进行精心设计的前瞻性队列研究是绝对必要的。
