综述：hCG、子痫前期和调节性 T 细胞。
Review: hCG, preeclampsia and regulatory T cells.
机构信息
Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, Providence, RI 02905, USA.
出版信息
Placenta. 2011 Mar;32 Suppl 2(Suppl 2):S182-5. doi: 10.1016/j.placenta.2011.01.009. Epub 2011 Feb 4.
Abstract
Human chorionic gonadotropin (hCG) is crucial for successful pregnancy. Its many functions include angiogenesis and immune regulation. Despite years of research, the etiology of preeclampsia remains unknown. Marked by insufficient trophoblast invasion and poor spiral artery remodeling, preeclampsia has also been linked to immune dysregulation. Here we discuss the roles of hCG in the context of endovascular cross-talk between trophoblasts and endothelial cells and immune tolerance. We propose that functional and glycosylation modifications of hCG may contribute to the pathogenesis of preeclampsia.
摘要
人绒毛膜促性腺激素（hCG）对于成功妊娠至关重要。其多种功能包括血管生成和免疫调节。尽管经过多年研究，子痫前期的病因仍不清楚。其特征为滋养细胞侵袭不足和螺旋动脉重塑不良，也与免疫失调有关。在这里，我们讨论 hCG 在滋养细胞和内皮细胞之间的血管内相互作用和免疫耐受背景下的作用。我们提出 hCG 的功能和糖基化修饰可能有助于子痫前期的发病机制。
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