Department of Radiation Oncology, University Medical Center Groningen, The Netherlands.
Radiother Oncol. 2011 Mar;98(3):357-9. doi: 10.1016/j.radonc.2010.12.008. Epub 2011 Feb 3.
This pilot study was undertaken to examine the ability of (18)F-3'-fluoro-3'-deoxy-l-thymidine positron emission tomography ((18)F-FLT-PET)to detect rectal cancer, to identify pathologic lymph nodes and to determine the accuracy of tumour length estimation in comparison with computer tomography (CT).
Nine patients with biopsy proven rectal cancer underwent CT and (18)F-FLT-PET scanning prior to short-term pre-operative radiotherapy (5×5Gy). Within 10 days after the start of radiotherapy a surgical resection was performed. Tumour lengths and regional lymph node visualisation on both imaging modalities were compared with pathology findings.
All tumours were visible on CT. (18)F-FLT-PET visualised 7 out of 9 tumours (78%). The pathology-based tumours lengths correlated better with CT as compared to FLT-PET(r=0.91, p<0.01). (18)F-FLT-PET was not able to visualise pathologic lymph nodes. However, CT identified all patients with pathologic lymph nodes.
Primary rectal cancer can be visualised by (18)F-FLT-PET in the majority of cases but not in all. However, (18)F-FLT-PET was not able to identify pathologic lymph nodes. Therefore, we conclude that (18)F-FLT-PET has limited value for the detection of pathologic lymph nodes and tumour delineation in rectal cancer.
本初步研究旨在探讨（18）F-3'-氟-3'-去氧-l-胸苷正电子发射断层扫描（（18）F-FLT-PET）检测直肠癌、识别病理淋巴结的能力，并与计算机断层扫描（CT）比较，确定肿瘤长度估计的准确性。
9 例经活检证实的直肠癌患者在短期术前放疗（5×5Gy）前接受 CT 和（18）F-FLT-PET 扫描。在放疗开始后 10 天内进行手术切除。比较两种影像学方法上的肿瘤长度和区域淋巴结显示与病理结果。
所有肿瘤均在 CT 上可见。（18）F-FLT-PET 显示 9 例肿瘤中的 7 例（78%）。基于病理的肿瘤长度与 CT 相比与 FLT-PET 相关性更好（r=0.91，p<0.01）。（18）F-FLT-PET 无法显示病理淋巴结。然而，CT 识别出所有有病理淋巴结的患者。
原发性直肠癌在大多数情况下可通过（18）F-FLT-PET 显示，但并非全部。然而，（18）F-FLT-PET 无法识别病理淋巴结。因此，我们得出结论，（18）F-FLT-PET 对直肠癌的病理淋巴结和肿瘤描绘具有有限的价值。
