Laboratory of Integrative Medicine for Lung, Inflammation and Cancers, Huashan Hospital, Fudan University, Shanghai 200040, China.
Chin Med J (Engl). 2009 Aug 5;122(15):1749-54.
This retrospective study evaluated the diagnostic accuracy of 2-(F18)-fluoro-2-deoxy-D-glucose-positron emission tomography ((18)F-FDG-PET)/computed tomography (PET/CT) in the preoperative diagnosis of metastatic mediastinal and hilar lymph node in patients with non-small-cell lung cancer (NSCLC).
A total of 39 patients received preoperative (18)F-FDG PET/CT and the postoperative biopsy. We compared preoperative PET/CT scan results with corresponding intraoperative histopathalogic findings in 39 NSCLC patients. The sensitivity, specificity, accuracy, positive and negative predictive value of (18)F-FDG PET/CT were assessed.
Histopathologic examination confirmed metastasis in 57 out of the 208 excised lymph nodes; 23 of the 57 nodes were mediastinal and hilar lymph nodes. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of PET/CT in the preoperative diagnosis of mediastinal lymph node metastasis in NSCLC patients were 65%, 96.8%, 92%, 78.5% and 90%, respectively.
PET/CT scan showed good accuracy in the preoperative diagnosis of mediastinal and hilar lymph node metastasis in the patients with NSCLC. We recommend that PET/CT scanning be used as a first-line evaluation tool for tumor diagnosis, therapy evaluation and follow-up.
本回顾性研究评估了 2-（F18）-氟-2-脱氧-D-葡萄糖正电子发射断层扫描（(18)F-FDG-PET）/计算机断层扫描（PET/CT）在非小细胞肺癌（NSCLC）患者术前诊断纵隔和肺门转移性淋巴结中的诊断准确性。
共 39 例患者接受了术前（18）F-FDG PET/CT 和术后活检。我们将 39 例 NSCLC 患者的术前 PET/CT 扫描结果与相应的术中组织病理学发现进行了比较。评估了（18）F-FDG PET/CT 的敏感性、特异性、准确性、阳性预测值和阴性预测值。
组织病理学检查证实 208 个切除的淋巴结中有 57 个发生转移；57 个淋巴结中有 23 个为纵隔和肺门淋巴结。PET/CT 对 NSCLC 患者纵隔淋巴结转移的术前诊断的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为 65%、96.8%、92%、78.5%和 90%。
PET/CT 扫描在 NSCLC 患者纵隔和肺门淋巴结转移的术前诊断中具有良好的准确性。我们建议将 PET/CT 扫描用作肿瘤诊断、治疗评估和随访的一线评估工具。
