（18）F-FDG PET/CT 在结直肠癌术后监测中的临床价值。

Clinical value of (18)F-FDG PET/CT in postoperative monitoring for patients with colorectal carcinoma.

机构信息

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, China.

出版信息

Cancer Epidemiol. 2011 Oct;35(5):497-500. doi: 10.1016/j.canep.2011.01.002. Epub 2011 Feb 5.

DOI:10.1016/j.canep.2011.01.002

PMID:21296635

Abstract

OBJECTIVE

To evaluate the clinical value of (18)F-FDG PET/CT in postoperative monitoring for patients with colorectal carcinoma.

METHODS

66 postoperative patients with colorectal carcinoma underwent whole-body FDG PET/CT. The final histopathological and formal clinical follow-up findings were used as gold standard to determine the sensitivity and specificity of FDG PET/CT and enhanced CT of the same periods.

RESULTS

The sensitivity and specificity of FDG PET/CT in detecting recurrence are 96.30%, 94.87% (while enhanced CT are 70.37% and 87.18% respectively). The sensitivity and specificity in detecting metastasis are 95.35%, 82.61% (enhanced CT are 61.90%, 75.00%). SUVmax was significantly higher in malignant lesions [range 4.16-22.00, mean±standard deviation (x±s) 8.06±4.30] than in benign ones (range 1.18-6.25, x±s 2.82±1.02).

CONCLUSION

At present, whole-body (18)F-FDG PET/CT is an advanced diagnostic imaging technique in detecting loco-regional recurrence and metastasis in postoperative patients with colorectal carcinoma for its higher sensitivity and specificity.

摘要

目的

评估（18）F-FDG PET/CT 在结直肠癌术后监测中的临床价值。

方法

66 例结直肠癌术后患者行全身 FDG PET/CT 检查。以最终的组织病理学和正式临床随访结果为金标准，确定 FDG PET/CT 与同期增强 CT 的灵敏度和特异性。

结果

FDG PET/CT 在检测复发方面的灵敏度和特异性分别为 96.30%、94.87%（而增强 CT 分别为 70.37%和 87.18%）。FDG PET/CT 在检测转移方面的灵敏度和特异性分别为 95.35%、82.61%（增强 CT 分别为 61.90%、75.00%）。恶性病变的 SUVmax 显著高于良性病变[范围 4.16-22.00，平均值±标准差（x±s）为 8.06±4.30]。