Eidemüller Markus, Holmberg Erik, Jacob Peter, Lundell Marie, Karlsson Per
Helmholtz Zentrum München, Institute of Radiation Protection, 85764 Neuherberg, Germany.
Radiat Prot Dosimetry. 2011 Feb;143(2-4):375-9. doi: 10.1093/rpd/ncq473. Epub 2011 Feb 4.
Swedish hemangioma patients were treated in infancy mainly by external application of radium-226 starting from 1920. This work analysed the radiation risk among 17,158 women with a total of 678 breast cancer incidence cases with models of carcinogenesis and empirical excess relative risk models. Models incorporating effects of genomic instability were developed and applied to the hemangioma cohort. The description of the radiation risk was significantly improved with a model of genomic instability at an early stage of carcinogenesis.
从1920年起，瑞典的血管瘤患者在婴儿期主要接受镭-226的外部照射治疗。这项研究利用致癌模型和经验性超额相对风险模型，分析了17158名女性中的辐射风险，这些女性共有678例乳腺癌发病病例。开发了纳入基因组不稳定性影响的模型，并将其应用于血管瘤队列。在致癌作用早期阶段，采用基因组不稳定性模型可显著改善对辐射风险的描述。
