Colotto Marco, Maranghi Marianna, Durante Cosimo, Rossetti Marco, Renzi Alessandra, Anatra Maria Grazia
Department of Internal Medicine and Medical Specialties, Policlinico Umberto I, University of Rome Sapienza, Rome, Italy.
Intern Med. 2011;50(3):223-5. doi: 10.2169/internalmedicine.50.4421. Epub 2011 Feb 1.
Since its clinical definition in 1987, the syndrome called, "periodic fever, aphtous stomatitis, pharyngitis and cervical adenitis" syndrome (PFAPA) has been considered peculiar to pediatric age. In the recent literature there are a few case reports of PFAPA in adults. We describe a case of a 21-year-old female affected by PFAPA who presented a history of tonsillectomy at the age of four. To our knowledge this is the fourth case described with a diagnosis of PFAPA in an adult with a history of tonsillectomy during childhood. Although the role of tonsillectomy in the treatment of PFAPA is still controversial, due to the lack of definitive data in literature, this case suggests that fever episodes may relapse several years after surgery.
自1987年其临床定义以来，被称为“周期性发热、口疮性口炎、咽炎和颈淋巴结炎”综合征（PFAPA）一直被认为是儿童期特有的综合征。最近的文献中有几例成人PFAPA的病例报告。我们描述了一例21岁患PFAPA的女性病例，该患者四岁时曾行扁桃体切除术。据我们所知，这是第四例诊断为PFAPA的成年病例，其童年时有扁桃体切除史。尽管扁桃体切除术在PFAPA治疗中的作用仍存在争议，由于文献中缺乏确凿数据，但该病例表明发热发作可能在手术后数年复发。
