Sakamaki Yusuke, Hayashi Matsuhiko, Wakino Shu, Fukuda Seiichi, Konishi Kounosuke, Hashiguchi Akinori, Hayashi Koichi, Itoh Hiroshi
Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University, Japan.
Intern Med. 2011;50(3):233-8. doi: 10.2169/internalmedicine.50.4020. Epub 2011 Feb 1.
We report a case of membranous nephropathy with primary biliary cirrhosis (PBC). A 76-year-old Japanese man had been treated for PBC and was referred to our department because of acute severe proteinuria (10 g/day). Renal biopsy was performed and was compatible with a diagnosis of membranous nephropathy. The patient was treated with cyclosporine A (CsA; Neoral®), which was followed by normalization of liver function and partial remission of proteinuria (0.68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC.
我们报告一例伴有原发性胆汁性肝硬化（PBC）的膜性肾病病例。一名76岁的日本男性因PBC接受治疗，因急性重度蛋白尿（10克/天）转诊至我科。进行了肾活检，结果符合膜性肾病的诊断。患者接受了环孢素A（CsA；新山地明®）治疗，随后肝功能恢复正常，蛋白尿部分缓解（0.68克/天），且在六个月内未出现任何明显副作用。该病例表明，CsA单一疗法对治疗与PBC相关的肝功能障碍和膜性肾病均有效。
