Yamauchi Kohei, Shikanai Toshiki, Nakamura Yutaka, Kobayashi Hitoshi, Ogasawara Masahito, Maeyama Kazutaka
Division of Pulmonary Medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine.
Yakugaku Zasshi. 2011 Feb;131(2):185-91. doi: 10.1248/yakushi.131.185.
Histamine has been reported to play an important role in pathogenesis of bronchial asthma. However, H1-blockers are not recommended as the first drug for asthma therapy in the guidelines. Histamine may play various roles in allergic airway inflammation through the H1 receptor (H1R), H2R, and H4R in immune cells including T lymphocytes and dendritic cells. We therefore evaluated its role in allergic airway inflammation with the use of histamine-deficient mice. The results suggested that histamine plays a role in the prevention of goblet cell hyperplasia. Organic cation transporter-3 (OCT-3) is thought to be a transporter of histamine. Polymorphism of OCT-3 {R120R (T/C)} was associated with the severity of asthma. Recently, it has been proposed that both asthma and allergic rhinitis should be treated as a single airway disease. Comorbidity of asthma and allergic rhinitis is very high (70-80%) and they share similar allergic inflammation. H1-blockers are recommended as first-line drugs to treat allergic rhinitis in the guidelines. Therefore H1-blockers are strongly recommended for patients with both asthma and allergic rhinitis.
据报道，组胺在支气管哮喘的发病机制中起重要作用。然而，在指南中，H1受体阻滞剂不被推荐作为哮喘治疗的首选药物。组胺可能通过免疫细胞（包括T淋巴细胞和树突状细胞）中的H1受体（H1R）、H2R和H4R在过敏性气道炎症中发挥多种作用。因此，我们使用组胺缺陷小鼠评估了其在过敏性气道炎症中的作用。结果表明，组胺在预防杯状细胞增生中起作用。有机阳离子转运体3（OCT-3）被认为是组胺的转运体。OCT-3{R120R（T/C）}的多态性与哮喘的严重程度相关。最近，有人提出哮喘和过敏性鼻炎应被视为单一气道疾病进行治疗。哮喘和过敏性鼻炎的合并症非常高（70-80%），且它们具有相似的过敏性炎症。在指南中，H1受体阻滞剂被推荐作为治疗过敏性鼻炎的一线药物。因此，强烈推荐H1受体阻滞剂用于患有哮喘和过敏性鼻炎的患者。
