Michael S D, De Angelo L, Kaikis-Astaras A
Department of Biological Sciences, State University of New York, Binghamton 13901.
Autoimmunity. 1990;6(1-2):1-12. doi: 10.3109/08916939008993365.
Interactions between the immune and endocrine systems may have an important role in ovarian tumorigenesis. Neonatal thymectomy at 3 days of age (Tx-3) in (C3H/HeMs x 129/J)F1 (C31) female mice results in an autoimmune ovarian dysgenesis then subsequent tumor formation. At 3 months of age the histology of the ovaries showed that approximately 60% of the Tx-3 mice (Tx-3 DO) had completely lost their oocytes and follicles so that a preponderance of interstitial-like cells remained. The remainder of the Tx-3 mice had atypical ovaries (Tx-3 AO). The vaginal cytology showed that both groups of Tx-3 mice became acyclic at an early age compared to the intact mice. Around 12 months of age, a high percentage of the dysgenic ovaries developed trabecular tumors. Plasma protein-related indicators of systemic inflammatory responses showed little change during the course of the autoimmune oophoritis or ovarian tumorigenesis. Levels of estradiol 17 beta (E2) and testosterone (T) did not vary in the Tx-3 mice compared to those of the intact mice through 21 months of age but progesterone levels were lower during the exacerbation of the autoimmune oophoritis and tumor development. By 24 months of age levels of P increased while E2 decreased. Apparently, the premature reproductive failure in these mice at a young-adult stage results from the early loss of the oocytes by the localized autoimmune insult to the ovaries. The autoimmune oophoritis may then be the primary trigger for the subsequent ovarian tumor formation and the tumors succeed in association with the altered hormonal milieu.
免疫系统和内分泌系统之间的相互作用可能在卵巢肿瘤发生中起重要作用。对（C3H/HeMs×129/J）F1（C31）雌性小鼠在3日龄时进行新生期胸腺切除（Tx - 3），会导致自身免疫性卵巢发育不全，随后形成肿瘤。3月龄时卵巢组织学检查显示，约60%的Tx - 3小鼠（Tx - 3 DO）完全失去了卵母细胞和卵泡，只剩下大量间质样细胞。其余Tx - 3小鼠有非典型卵巢（Tx - 3 AO）。阴道细胞学检查表明，与未处理小鼠相比，两组Tx - 3小鼠在幼年时就出现了无周期性变化。约12月龄时，高比例的发育不全卵巢发生了小梁肿瘤。全身性炎症反应的血浆蛋白相关指标在自身免疫性卵巢炎或卵巢肿瘤发生过程中变化不大。与未处理小鼠相比，Tx - 3小鼠在21月龄前17β - 雌二醇（E2）和睾酮（T）水平没有变化，但在自身免疫性卵巢炎加重和肿瘤发展期间孕酮水平较低。到24月龄时，孕酮水平升高而E2水平降低。显然，这些小鼠在成年早期出现的过早生殖功能衰竭是由于卵巢受到局部自身免疫损伤导致卵母细胞早期丢失所致。自身免疫性卵巢炎可能是随后卵巢肿瘤形成的主要触发因素，并且肿瘤的发生与激素环境的改变有关。
