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p16(Ink4a) 在癌症中的过表达：与衰老和高级别肿瘤相关的抑癌基因。

p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.

机构信息

Pathology Department, Fundació Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.

出版信息

Oncogene. 2011 May 5;30(18):2087-97. doi: 10.1038/onc.2010.614. Epub 2011 Feb 7.

DOI:10.1038/onc.2010.614
PMID:21297668
Abstract

p16(Ink4a) is a protein involved in regulation of the cell cycle. Currently, p16(Ink4a) is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16(Ink4a) has also been described in several tumors. This review attempts to elucidate when and why p16(Ink4a) overexpression occurs, and to suggest possible implications of p16(Ink4a) in the diagnosis, prognosis and treatment of cancer.

摘要

p16(Ink4a) 是一种参与细胞周期调控的蛋白质。目前，p16(Ink4a) 因其生理作用和在大量肿瘤中的下调表达而被认为是一种肿瘤抑制蛋白。有趣的是，在几种肿瘤中也描述了 p16(Ink4a) 的过表达。本综述试图阐明 p16(Ink4a) 过表达发生的时间和原因，并提出 p16(Ink4a) 在癌症的诊断、预后和治疗中的可能意义。

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