三环类和四环类抗抑郁药的心血管作用。
Cardiovascular effects of tricyclic and tetracyclic antidepressants.
出版信息
Can Fam Physician. 1979 May;25:619-25.
Abstract
This article reviews all available studies on the cardiovascular effects of tri- and tetracyclic antidepressants at therapeutic and toxic levels. There is growing evidence that tricyclics, even at therapeutic levels, can be cardiotoxic. Plasma TCA levels are too variable to define a safe therapeutic range. Any patient showing cardiovascular side effects should have an ECG before continuing medication.
摘要
这篇文章综述了所有关于三环和四环抗抑郁药在治疗和中毒水平下对心血管影响的研究。越来越多的证据表明，三环类药物即使在治疗水平也可能具有心脏毒性。血浆 TCA 水平变化太大，无法定义安全的治疗范围。任何出现心血管副作用的患者在继续用药前都应该进行心电图检查。
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Pharmacological studies with tofranil.多虑平的药理学研究。
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INHIBITION OF NORADRENALINE UPTAKE BY DRUGS.药物对去甲肾上腺素摄取的抑制作用。
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