Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, 1665 University Boulevard, Birmingham, AL 35294-0022, USA.
Curr Hypertens Rep. 2011 Jun;13(3):187-91. doi: 10.1007/s11906-011-0190-2.
Vitamin D belongs to the family of nuclear steroid hormones, which has pleiotropic effects on several organ systems. Different vitamin D compounds have been studied as potential cardioprotective agents over the past 20 years. The results of these clinical studies vary based on the form and dosage of vitamin D administered during the trial. In the past 5 years, many have described an association of vitamin D compounds and cardiovascular health through reduction in blood pressure, reduction in inflammatory biomarkers, improved insulin sensitivity, and reduction in cardiovascular disease complications and death. Because there are several vitamin D compounds, it is important to consider the full breadth of the literature when examining vitamin D and cardiovascular health, to assist in hypothesis generation and understanding of the current state of the science. Although a growing body of evidence suggests that nutritional vitamin D supplementation and potentially even treatment with synthetic analogues of vitamin D may be cardioprotective, relatively few studies have examined either of these compounds in a randomized, controlled fashion. Studies examining the benefit of vitamin D supplementation are now beginning, but future studies considering calcitriol and analogue therapy also seem warranted.
维生素 D 属于核甾体激素家族，对多个器官系统具有多种作用。在过去的 20 年中，人们研究了不同的维生素 D 化合物作为潜在的心脏保护剂。这些临床研究的结果因试验期间给予的维生素 D 形式和剂量而异。在过去的 5 年中，许多人通过降低血压、降低炎症生物标志物、提高胰岛素敏感性以及减少心血管疾病并发症和死亡，描述了维生素 D 化合物与心血管健康之间的关联。由于有几种维生素 D 化合物，因此在检查维生素 D 和心血管健康时，必须考虑到文献的全貌，以帮助生成假说并了解当前科学的状况。尽管越来越多的证据表明，营养性维生素 D 补充剂，甚至可能用合成的维生素 D 类似物进行治疗，都可能具有心脏保护作用，但相对较少的研究以随机、对照的方式研究了这两种化合物中的任何一种。目前正在开始研究维生素 D 补充剂的益处，但似乎也有必要进行考虑钙三醇和类似物治疗的未来研究。
