Siripongpreeda Natawan, Hattasingh Weerawan, Amornvipas Patcharin, Eampokalap Boonchuay, Sakoolgnam Supachat, Pancharoen Chitsanu, Thisyakorn Usa
Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand.
J Med Assoc Thai. 2010 Nov;93 Suppl 5:S1-5.
This study assessed clinical differences between invasive pneumococcal disease (IPD) caused by penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae.
Patients with IPD confirmed during January 1996-December 2007 at three hospitals were included. Clinical characteristics and outcomes were compared between patients infected with penicillin-resistant Streptococcus pneumoniae (PRSP) and penicillin-sensitive Streptococcus pneumoniae (PSSP).
Sixty-nine patients with IPD were identified during the study period, 20 (29%) of whom were infected with PRSP and 49 (71%) with PSSP. Sex, mean age, underlying diseases and seasonal variation did not differ statistically between the two groups. No significant differences were identified in clinical course as measured by time until defervescence, duration of hospitalization and clinical outcome. Minimum inhibitory concentrations (MIC) for other antibiotics were determined; 20% and 10% of PRSP isolates were nonsusceptible to cephalosporins and meropenem, respectively, but all isolates were sensitive to vancomycin.
There were no significant differences identified in the clinical epidemiology of lPD cases caused by PRSP and PSSP.
本研究评估了由耐青霉素和对青霉素敏感的肺炎链球菌引起的侵袭性肺炎球菌病（IPD）之间的临床差异。
纳入1996年1月至2007年12月期间在三家医院确诊的IPD患者。比较感染耐青霉素肺炎链球菌（PRSP）和对青霉素敏感肺炎链球菌（PSSP）患者的临床特征和结局。
研究期间共确定69例IPD患者，其中20例（29%）感染PRSP，49例（71%）感染PSSP。两组在性别、平均年龄、基础疾病和季节变化方面无统计学差异。在以退热时间、住院时间和临床结局衡量的临床病程方面未发现显著差异。测定了其他抗生素的最低抑菌浓度（MIC）；分别有20%和10%的PRSP分离株对头孢菌素和美罗培南不敏感，但所有分离株对万古霉素敏感。
由PRSP和PSSP引起的IPD病例的临床流行病学未发现显著差异。
