Voiglio E, Gorry F, Margonari J, Faure J L
Laboratoire de Chirurgie expérimentale et de Microchirurgie, INSERM U 80, CNRS, URA 1177, hôpital Edouard-Herriot, Lyon.
Chirurgie. 1990;116(8-9):690-8.
A multiple organ block is composed of "en bloc" removed organs, connected by the vascular system, whose blood circulation is maintained by the heart, and oxygenation by the lungs under artificial ventilation. To develop the removal technique and the reanimation proceeding, and to validate this new physiological model, we used 70 Wistar rats. Some multiple organ blocks (heart-lungs, liver, pancreas, kidneys and bowel) functioned in vitro at 37 degrees C for more than 150 minutes with stable haemodynamics and preserved electrolyte and acid-base balances. Bile secretion and bilateral diuresis were present. Histopathological examination confirmed the integrity of these different organs. This physiological model could be used for the study of new preservation solutions.
多器官块由“整块”切除的器官组成，这些器官通过血管系统相连，其血液循环由心脏维持，在人工通气下由肺进行氧合。为了开发切除技术和复苏程序，并验证这个新的生理模型，我们使用了70只Wistar大鼠。一些多器官块（心肺、肝脏、胰腺、肾脏和肠道）在37摄氏度下体外功能运行超过150分钟，血流动力学稳定，电解质和酸碱平衡得以维持。有胆汁分泌和双侧利尿现象。组织病理学检查证实了这些不同器官的完整性。这个生理模型可用于新型保存液的研究。
