Arnoux R, Dufourcq J, Smeesters C, Lalanne J, Deminière C, Penin E, Clerc M, Poteaux L, Dartigues J F, Michel A
Clinique chirurgicale du C.H.R., Bordeaux.
Chirurgie. 1990;116(8-9):699-703.
A preparation of cyclosporine A (CsA) in small liposomes (300 nm) was tested in a rat model of heterotopic cardiac allograft. At a daily dose of 1,5 mg/kg during 14 days, the graft survival rate was 30.4 +/- 2.8 days with a liposome-CsA solution versus 16 +/- 2.3 days with a Cremophore-CsA solution (p less than 0.01). Animals treated with the liposome-CsA preparation exhibited less weight loss than animals treated with cremophore-CsA solution (p less than 0.01). It is likely that the up-take of CsA by macrophages, when incapsulated into liposomes is dramatically enhanced; these cells have been pointed out at targets for IL2 inhibition by CsA.
在异位心脏同种异体移植大鼠模型中测试了小脂质体（300纳米）包裹的环孢素A（CsA）制剂。在14天内每日剂量为1.5毫克/千克时，脂质体-CsA溶液组的移植物存活时间为30.4±2.8天，而聚氧乙烯蓖麻油- CsA溶液组为16±2.3天（p<0.01）。用脂质体-CsA制剂治疗的动物体重减轻比用聚氧乙烯蓖麻油-CsA溶液治疗的动物少（p<0.01）。当CsA被包裹在脂质体中时，巨噬细胞对其摄取可能会显著增强；这些细胞已被指出是CsA抑制白细胞介素2的靶点。
