Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37604, USA.
Int J Toxicol. 2011 Mar;30(2):197-206. doi: 10.1177/1091581810390824. Epub 2011 Feb 7.
2-Chloroethyl ethyl sulfide (CEES) or half-mustard gas, a sulfur mustard (HD) analog, is a genotoxic agent that causes oxidative stress and induces both apoptotic and necrotic cell death. Sodium pyruvate induced a necrosis-to-apoptosis shift in HaCaT cells exposed to CEES levels ≤ 1.5 mmol/L and lowered markers of DNA damage, oxidative stress, and inflammation. This study provides a rationale for the future development of multicomponent therapies for HD toxicity in the skin. We hypothesize that a combination of pyruvates with scavengers/antioxidants encapsulated in liposomes for optimal local delivery should be therapeutically beneficial against HD-induced skin injury. However, the latter suggestion should be verified in animal models exposed to HD.
2-氯乙基乙基硫醚（CEES）或芥子气（HD）类似物，是一种遗传毒性物质，可引起氧化应激，并诱导细胞凋亡和坏死。丙酮酸钠可诱导暴露于 CEES 水平≤1.5mmol/L 的 HaCaT 细胞由坏死向凋亡转变，并降低 DNA 损伤、氧化应激和炎症的标志物。本研究为未来开发用于皮肤 HD 毒性的多成分治疗提供了依据。我们假设，将丙酮酸与脂质体包封的清除剂/抗氧化剂联合使用，以实现最佳局部递送，应该对 HD 诱导的皮肤损伤具有治疗益处。然而，这一建议尚需在暴露于 HD 的动物模型中进行验证。
