苯并咪唑类似物抑制人类疱疹病毒 6。
Benzimidazole analogs inhibit human herpesvirus 6.
机构信息
University of Alabama School of Medicine, 1600 6th Avenue South, 128 Children's Harbor Building, Birmingham, AL 35233, USA.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2442-5. doi: 10.1128/AAC.01523-10. Epub 2011 Feb 7.
Abstract
Several benzimidazole nucleoside analogs, including 1H-β-D-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 1H-β-L-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir [MBV]), inhibit the replication of human cytomegalovirus. Neither analog inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional analogs of these compounds were evaluated against both variants of HHV-6, and two L-analogs of BDCRB had good antiviral activity against HHV-6A, as well as more modest inhibition of HHV-6B replication.
摘要
几种苯并咪唑核苷类似物，包括 1H-β-D-核糖呋喃基-2-溴-5,6-二氯苯并咪唑（BDCRB）和 1H-β-L-核糖呋喃基-2-异丙基氨基-5,6-二氯苯并咪唑（maribavir [MBV]），可抑制人巨细胞病毒的复制。这些类似物都没有抑制相关的β疱疹病毒人疱疹病毒 6（HHV-6）。这些化合物的其他类似物针对两种 HHV-6 变体进行了评估，BDCRB 的两种 L 类似物对 HHV-6A 具有良好的抗病毒活性，对 HHV-6B 的复制也有适度的抑制作用。
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