University of Alabama School of Medicine, 1600 6th Avenue South, 128 Children's Harbor Building, Birmingham, AL 35233, USA.
Antimicrob Agents Chemother. 2011 May;55(5):2442-5. doi: 10.1128/AAC.01523-10. Epub 2011 Feb 7.
Several benzimidazole nucleoside analogs, including 1H-β-D-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (BDCRB) and 1H-β-L-ribofuranosyl-2-isopropylamino-5,6-dichlorobenzimidazole (maribavir [MBV]), inhibit the replication of human cytomegalovirus. Neither analog inhibited the related betaherpesvirus human herpesvirus 6 (HHV-6). Additional analogs of these compounds were evaluated against both variants of HHV-6, and two L-analogs of BDCRB had good antiviral activity against HHV-6A, as well as more modest inhibition of HHV-6B replication.
几种苯并咪唑核苷类似物，包括 1H-β-D-核糖呋喃基-2-溴-5,6-二氯苯并咪唑（BDCRB）和 1H-β-L-核糖呋喃基-2-异丙基氨基-5,6-二氯苯并咪唑（maribavir [MBV]），可抑制人巨细胞病毒的复制。这些类似物都没有抑制相关的β疱疹病毒人疱疹病毒 6（HHV-6）。这些化合物的其他类似物针对两种 HHV-6 变体进行了评估，BDCRB 的两种 L 类似物对 HHV-6A 具有良好的抗病毒活性，对 HHV-6B 的复制也有适度的抑制作用。
