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[腔隙性梗死所致同侧单瘫病例:关于病理机制的思考]

[Case of ipsilateral monoparesis by lacunar infarction: a consideration on the pathological mechanism].

作者信息

Taniguchi Akira, Ii Yuichiro, Kawana Yosuke, Asahi Masaru, Naito Yutaka, Shibata Masunari, Maeda Masayuki, Tomimoto Hidekazu

机构信息

Department of Neurology, Mie University Graduate School of Medicine and Yamada Red Cross Hospital, Mie, Japan.

出版信息

Brain Nerve. 2011 Feb;63(2):177-80.

Abstract

An 81-year-old man had sudden-onset dysarthria and weakness in the right leg, and was admitted to our hospital in July 2009. Neurological examination showed right leg monoparesis, sensory disturbance on the right limbs, dysarthria, and decreased deep tendon reflexes. Brain MRI revealed an acute lacunar infarction in the right corona radiata and an old lacunar infarction in the left centrum semiovale, which occurred 4 years before. MR tractography disclosed impaired motor fibers in the right corona radiata, and transcranial magnetic stimulation (TMS) suggested diminished innervation from the bilateral cerebral cortices to the right leg. These results collectively indicated that reorganization of the pyramidal fibers were responsible for the monoparesis ipsilateral to the lacunar infarction, although anomalous pyramidal fibers with ipsilateral innervation were responsible for ipsilateral hemiplegia a previous study.

摘要

一名81岁男性突发构音障碍和右腿无力,于2009年7月入住我院。神经系统检查显示右腿单瘫、右下肢感觉障碍、构音障碍和腱反射减弱。脑部MRI显示右侧放射冠急性腔隙性梗死和左侧半卵圆中心陈旧性腔隙性梗死,后者发生于4年前。磁共振神经纤维束成像显示右侧放射冠运动纤维受损,经颅磁刺激(TMS)提示双侧大脑皮层至右腿的神经支配减弱。这些结果共同表明,锥体纤维的重组是腔隙性梗死同侧单瘫的原因,尽管先前的一项研究表明,具有同侧神经支配的异常锥体纤维是同侧偏瘫的原因。

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