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PEAK1, a novel kinase target in the fight against cancer.

作者信息

Kelber Jonathan A, Klemke Richard L

出版信息

Oncotarget. 2010 Jul;1(3):219-223. doi: 10.18632/oncotarget.128.

DOI:10.18632/oncotarget.128
PMID:21301050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3057678/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3f/3157718/6b53f22a13f0/oncotarget-01-219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3f/3157718/516f3102ce28/oncotarget-01-219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3f/3157718/6b53f22a13f0/oncotarget-01-219-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3f/3157718/516f3102ce28/oncotarget-01-219-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cb3f/3157718/6b53f22a13f0/oncotarget-01-219-g002.jpg

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2
p130Cas is an essential transducer element in ErbB2 transformation.Cas 是 ErbB2 转化中的一个重要转导元件。
FASEB J. 2010 Oct;24(10):3796-808. doi: 10.1096/fj.10-157347. Epub 2010 May 26.
3
The regulatory crosstalk between kinases and proteases in cancer.癌症中激酶和蛋白酶的调控串扰。
去势前后犬良性前列腺增生的血清蛋白质组比较分析
Animals (Basel). 2023 Dec 14;13(24):3853. doi: 10.3390/ani13243853.
4
Evaluation of SgK269 expression in colon cancer patients and the effects of hAMSCs secretome on tumor invasion through SgK269/c-Src/p-P130Cas/p-Paxillin/p-ERK1/2 signaling pathway in HT-29 colon cancer cells.评估结肠癌患者中SgK269的表达以及人脂肪间充质干细胞分泌组通过SgK269/c-Src/p-P130Cas/p-桩蛋白/p-细胞外信号调节激酶1/2信号通路对HT-29结肠癌细胞侵袭的影响。
3 Biotech. 2023 Nov;13(11):346. doi: 10.1007/s13205-023-03763-0. Epub 2023 Sep 22.
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Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.PEAK 伪激酶相互作用的结构图谱鉴定出 14-3-3 为 PEAK3 信号的分子开关。
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Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals.伪足丰富的非典型激酶 1（PEAK1）通过激活 JAK/STAT3 信号促进黑色素瘤细胞的侵袭和转移。
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